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KMID : 0356719960120010137
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Journal of the Korean Society of Coloproctology
1996 Volume.12 No. 1 p.137 ~ p.148
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Analysis of Correlation between DNA Ploidy and Proliferative Activity with Previous Prognostic Parameter of Colorectal Carcinoma
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Kim Sang-Chul
Kim Dae-Sung
Rhoe Byung-Sun
Yoon Gwang-Soo
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Abstract
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This study was designed to determine the reliability of DNA analysis in predicting outcome of patients with colorectal carcinoma and evaluated for the correlation of clinicopathologic parameters with DNA analysis as a prognostic factor of colorectal carcinoma. Eighty-five patients who underwent curative resection for colorectal carcinoma were examined for DNA ploidy, S-phase fraction and proliferative index by flow cytometry. 20 cases(23.6%) were DNA diploid, 65 cases(76.4%) were DNA aneuploid. The frequency of DNA aneuploid was noted higher as the poorer histologic grade, positive lymph node involvement and grossly ulceroinfiltrative pattern of tumor(p<0.05). The frequency of high S-phase fraction (S.P.F>20%), high proliferative index(P.I>30%) was noted higher as the poorer histologic grade, increased Duke’s stage
and positive lymph node involvement(p< 0.05). In patients with aneuplid with high S-phase fraction(S.P.F>20%) group, ratio of death, recurrence were significantly poor than those with aneuplid alone and diploid group(28.2% Vs 15.1% Vs 15%, p< 0.05). As the result of this study, we conclude that flow cytometric analysis of DNA content, histologic grade, Duke’s stave, lymph node involvement and gross pattern of tumor were significance prognostic factors in patients with colorectal carcinoma and provide more accurate assessment of outcome.
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KEYWORD
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Colorectal Neoplasms, Flow Cytometry
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